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Subsequently summarized in J

No difference in HDL cholesterol was observed between the groups

Importantly, new or worsening skin symptoms should never be dismissed

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Most clinical evidence suggests that continuous therapy yields better results than stopping, since appetite hormones rebound when the medication ends

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5