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doi: 10.18632/aging.101759 223 OkaJSuzukiEKondoY

They are rarely tested in large human studies, and small short-term studies do not provide strong evidence 16

The Diabetes Control and Complications Trial (DCCT), a prospective randomized controlled trial of intensive (mean A1C about 7% [53 mmol/mol]) versus standard (mean A1C about 9% [75 mmol/mol]) glycemic control in patients with type 1 diabetes, showed definitively that better glycemic control is associated with 5076% reductions in rates of development and progression of microvascular (retinopathy, neuropathy, and diabetic kidney disease) complications

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