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But its origins are the key to its primary function

Malnutrition leads to an imbalance in amino acids, characterized by decreased BCAAs and increased aromatic amino acids, resulting in reduced mammalian target of rapamycin signaling, impaired protein synthesis, hypoalbuminemia, and ultimately worsening of HE [41, 79, 80]

This rapid GSH loss disrupts redox homeostasis, promotes ROS accumulation, and facilitates redox-dependent protein modifications that drive apoptotic commitment