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On a therapeutic note, some microbiota-targeted treatments have reduced protein aggregates in models: long-term broad-spectrum antibiotics reduced A deposition and microglial reactivity in an AD mouse model, and recolonization with a simplified microbiota reversed some of these effects, indicating that specific microbial communities can either exacerbate or ameliorate protopathic cascades [102]
The FDA has pushed back on this strategy in several high-profile cases, but the tactic remains part of the innovator defensive toolkit
10.3390/biotech12020029 18 LevineR
Increased melanin production and rate of tanning Melanotan I binds to the melanocortin 1 receptor (MC1R), thereby increasing melanin production
[DOI] [PubMed] [Google Scholar] 56.Janssen-Heininger Y.M.W., Nolin J., Hoffman S.M., van der Velden J., Tully J.E., Lahue K.G., Abdalla S.T., Chapman D., Reynaert N.L., van der Vliet A., et al
