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The available evidence is preclinically solid but limited in human medicine to a single field of application

This can make a noticeable difference in daily comfort and mobility, reducing stiffness and potentially making it easier to stay active

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In 2013 Tseng et al

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In physiological oral mucosal melanin hyperpigmentation there is no increase in the number of melanocytes, but there is increased melanin in melanocytes in the basal cell layer of the oral epithelium, in the melanocyte-keratinocyte units, and in the lamina propria within melanophages