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We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation

Fatty acyl lipids showed no significant differences

This can leave mitochondrial membranes, enzymes and DNA more vulnerable to oxidative injury

Later findings varied substantially according to species, route, timing and experimental conditions

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