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However, despite these advantages, the clinical use of native GLP-1 is significantly limited by its short plasma half-life (12 min), owing to rapid enzymatic degradation by DPP-4 and renal clearance

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It should be clear and colourless (or almost colourless)

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Because it stays active in the body for weeks, stopping it requires patience, planning, and realistic expectations

Crucially, GIP agonism helps buffer the nausea often associated with strong GLP-1 stimulation, allowing for better tolerance at higher dosages