Lancet: Diabetes and Endocrinology 2016
Given that gut microbiota imbalances may contribute to AD progression by promoting amyloid-beta accumulation, triggering inflammation, increasing oxidative damage, and impairing insulin signaling 45,82 , these findings highlight the possibility that modulation of gut-brain axis may be a key mechanism underlying the cognitive benefits of dual-action therapies in DM2-AD comorbidity
First, CKD patients may frequently have metabolic acidosis, which has been shown to result in thyroid status alterations (i.e., elevated TSH and low T4 and/or T3 levels) that may be improved with oral sodium citrate or sodium bicarbonate therapy
Dietary intake level of marine-derived DHA but not blood DHA concentration was also inversely associated with the risks of dementia and Alzheimer's disease
These genetic markers may help provide context for medication selection and support a more informed conversation between patient and provider about which treatment class aligns with individual predispositions
Drug-induced acute kidney injury: diverse mechanisms of tubular injury
