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Three dual agonists (peptide 15, MEDI0382 and SAR425899) and one triple agonist (peptide 20) were evaluated at GLP-1R and GCGR, relative to the native peptidic ligands (GLP-1 and glucagon)

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The semi-quantitative analysis indicated that the number of migrated cells in the PTK hydrogel, PTA hydrogel, and TA-treated groups was elevated by 6.4 to 6.9 times compared to that in the control group (Fig