The incidence and severity of these generalised reactions have not yet been fully characterised, as retatrutide's full adverse event profile is still being established through ongoing trials
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8,9,30 The agents used in these trials, including higher-dose semaglutide (2.4 mg) and the dual GLP-1/GIP receptor agonist tirzepatide, have demonstrated compelling benefits
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[1] [3] Patients with severe gastrointestinal disease may require careful consideration and monitoring
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