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Semaglutide side effects Common side effects of semaglutide are gastrointestinal-related and include: Nausea (44%) Diarrhea (30%) Vomiting (24%) Constipation (24%) Abdominal pain (20%) Headache (14%) Fatigue (11%) Serious side effects of semaglutide are inflammation of the pancreas (pancreatitis), gallbladder issues, changes in vision (diabetic retinopathy), suicidal ideation, low blood sugar levels (hypoglycemia) and hypersensitivity or allergic reaction to semaglutide

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