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For randomised clinical trials, the Jadad scale ( To complement the Jadad score, the Cochrane Risk of Bias Tool (RoB 2) ( For observational studies (cohort and case-control), the NewcastleOttawa Scale (NOS) ( Risk of bias was interpreted as follows: i) Low risk: All criteria met or no more than one rated as unclear

[1] [14] However, this doesn't mean all doses are completely without risk of adverse effects or interactions (for example, chloramphenicol may reduce the haematological response to B12)