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Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors a novel mechanism not shared by currently licensed treatments such as semaglutide or tirzepatide

If youre already on an SSRI thats working, theres usually no reason to switch just because another one has slightly better cardiovascular data

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High levels of oxidative stress may contribute to ALS onset, increasing motoneurons death, and heavy metals may be a cause for the increase of ROS

Nonetheless, this classical view has been challenged by the development of thiazolidinediones, which possess potent insulin-sensitizing properties despite having very low to absent PPAR-binding affinity 51

Al-Azzawy MA, Qader SM, Mirdan AA