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[1] Rushworth GF, Megson IL

Both classes are resistant to the enzymatic degradation seen for native GLP-1, which is cleaved by the DPP-IV enzyme to generate inactive metabolites and intact GLP-1 forms with low affinity for the GLP-1R

Rybelsus is an oral medication and works more slowly than others

The authors compared the metabolic profile to the diabetes drug metformin, but stopped short of saying the two are interchangeable