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Key findings from the Phase 2 trial included: Dose-dependent reductions in body weight across all active treatment arms Significant improvements in waist circumference, a key marker of visceral adiposity Reductions in fasting insulin levels and HbA1c Improvements in lipid profiles, including triglycerides Phase 3 trials are currently ongoing and are expected to include larger, more diverse populations with more granular subgroup analyses, including sex-specific data

BMP signaling is required for the generation of primordial germ cells in an insect

This means that GLP-1 therapies may gradually expand from specialist treatment settings to broader chronic disease management markets

Importantly, patients should report persistent or severe side effects

Malhi GS, Mann JJ

Mustelin, T