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Activation of PXR induces the expression of UGT1A1 the enzyme responsible for bilirubin glucuronidationas well as efflux transporters such as MRP2, enhancing bilirubin clearance from the liver

Kikuchi T, Cotton JA, Dalzell JJ, Hasegawa K, Kanzaki N, McVeigh P, et al

Modern liver-specific IGF-1 knockout studies have shown that local IGF-1 contributes substantially to tissue IGF1R activation, separate from the endocrine pool

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Introduction Have you ever spent a week feeling inexplicably sluggish, despite getting enough sleep

Moreover, a single biomarker could not sufficiently reflect the aging process across various biological systems