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Intravenous (IV) Delivery: Systemic infusion ensures broad CNS distribution while regulating systemic immune activation and cytokine imbalance associated with insomnia

Evidence is promising but pre-clinical

The 10 mg vial is freeze-dried for stability and can be reconstituted with bacteriostatic water to produce a clear solution for in vitro or preclinical use

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Although studies suggested that tryptophan and its derivatives could influence the gut microbiome and interact with the gut mucosal immune system, recent clinical investigations proposed that changes in immunity and kynurenine metabolism may trigger fatigue in ME/CFS but do not sustain it over time [61, 67, 68]

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