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In vitro studies have found that in IDH1 mutant glioma stem cells (TS603), the expression of genes related to ROS clearance is overall upregulated, and the gene that regulates glutathione synthesis, SLC7A11, is most upregulated

Abstract Oral squamous cell cancer (OSCC) is a major cause of death in developing nations

SS-31 for mitochondrial neuropathy SS-31 (Elamipretide) targets the inner mitochondrial membrane, stabilizing cardiolipin and improving electron transport chain efficiency

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Ferguson SD, Bindal S, Bassett RL, Haydu LE, McCutcheon IE, Heimberger AB, Li J, O'Brien BJ, Guha-Thakurta N, Tetzlaff MT, Tawbi H, Davies MA , Glitza IC

Creation of vectors & protein expression To create a model protein for purification, we chose to use the GFP for its solubility and ease of visualization [10]