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Where the Science Still Has Gaps Several questions remain unresolved: optimal dosing for therapeutic applications long-term systemic safety standardized clinical protocols large randomized human trials These gaps highlight the difference between promising experimental science and established clinical practice

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Nevertheless, to fully understand the long-term effects of the consumption of fermented foods, it is crucial that future studies have longer intervention periods and evaluate the GM composition, not only before and immediately after the intervention, but also some time after the cessation of the regime (e.g., several weeks)

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