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Diabetologia 37:7581 Damiao AO, Sipahi AM, Vezozzo DP, Goncalves AL, Habr-Gama A, Teixeira MG et al (1997) Effects of colectomy on gallbladder motility in patients with ulcerative colitis

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These Kupffer cell effects were also associated with hepatocellular damage in rats and Guinea pigs, however this finding was not observed in the Rhesus monkeys, suggesting that species differences are an important factor in PGN toxicity

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Small sample sizes: Published studies have involved relatively small numbers of subjects (dozens, not thousands)