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158 Inositol 1,4,5-trisphosphate receptors mediate ER Ca 2+ release and subsequent mitochondrial Ca 2+ accumulation, leading to cell senescence

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TXNRDs also serve as electron donors for the regeneration of small antioxidants, possibly recycling ascorbic acid (vitamin C), -lipoic acid, -tocopherol (vitamin E), and coenzyme Q 10 from their oxidized forms (8)

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