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Differential vascularization, marrow composition, and osteocyte density between trabecular and cortical compartments likely modulate these divergent responses, collectively explaining the distinct patterns of bone loss observed under CR in mice

Rare genetic diseases Transthyretin amyloidosis (ATTR) is a rare systemic disease characterized by the progressive deposition of misfolded TTR protein in the heart and peripheral nerves, leading to transthyretin amyloid polyneuropathy (ATTR-PN) and transthyretin amyloid cardiomyopathy (ATTR-CM)

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Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance