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Some individuals also experience confusion, disorientation, and sleep disturbances

There is a lot of excitement and demand for these medications, but side effects are critical points for discussion, Prateek Sharma, MD, a Professor of Medicine in the Department of Medical Oncology at the University of Kansas School of Medicine, and lead investigator of the study, told Healthline

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In a 52-week trial of pediatric insulin-experienced type 1 diabetes patients, 84.1% of patients who received TRESIBA were positive at baseline for anti-insulin degludec antibodies and 5.8% of patients developed anti-insulin degludec antibodies at least once during the trial

The absorption-enhancer workaround Rybelsus, oral semaglutide from Novo Nordisk, is the only FDA-approved oral GLP-1 receptor agonist as of April 2026, approved in 2019 for type 2 diabetes