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When KOA develops to the end stage, total knee arthroplasty is generally used to improve the living conditions of patients (Quinn et al., 2018)

10.1038/s41591-018-0104-9 Nat Med

10,11 CVS has been described in all ethnicities, but it is most common among Caucasians

The thiol group is important this sulfur compound allows glutathione to donate electrons to neutralize reactive oxygen species ( ROS ) in the cell

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So, to control the formation of melanin and aid with faster spot-lightening, we can use tyrosinase inhibitor skincare which can lighten those overly pigmented areas of skin and return them to their natural state