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doi: 10.1172/JCI117306

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After eight weeks, leg heaviness was reported to be reduced by 60.4% in the Pycnogenol group compared to a reduction of 12.6% in the placebo group

Physician-prescribed topical formulations deliver the peptide exactly where the benefits occur, at therapeutic concentrations (2 to 10 percent or more), without systemic distribution

Bauer, KA

Consequently, since the 1960s, the drug has been approved as an inhalation therapy for patients diagnosed with CF, but its effects on improving lung function or reducing pulmonary exacerbations have not yet been fully established [121,122]