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This effect reflects GH's role in tissue repair and protein synthesis enhancement
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Compound 22 , a hybrid with the N-terminal from 21 and the C-terminal from 16 demonstrated a further enhanced potency (Ki = 23 nM) and a high selectivity for IRAP over AP-N (Andersson et al., 2010)
Hori M, Hasegawa Y, Hayashi Y, Nakagami T, Harada-Shiba M
Additionally similar results are obtained upon treatment of osteoporotic and diabetic fractures in mice, and pain resolution is simultaneously accelerated by this approach
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