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However, these adverse effects were mitigated by the addition of the cryoprotectant trehalose (TRE) (Figure 4A, Figure S6)

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The catch is that this concentration does not scale to the higher end of the titration ladder: at 5 mg/mL a 5 mg dose already fills the entire 100-unit barrel, and 7.5 mg or more cannot be drawn in a single U-100 syringe at all

Oxidative stress can contribute to fatigue and low energy levels

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