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260,261 Furthermore, treatment with a histone deacetylase inhibitor in Shank3 -knockout mice significantly improves the behavioural phenotype of the mice, suggesting that abnormal histone modification is a potential mechanism of ASD

Moreover, clinical study outcomes support the use of probiotics as an adjunct in the MDD treatment, and determine the efficacy of psychobiotic therapy in aboriginal tribes with psychiatric conditions (119, 120)