This suggested a role for peritumoral and tumoral endothelial cells in tumor immune surveillance (19)
As an interesting result, a study using triple-knockout mice lacking cystathionine -synthase, cystathionine -lyase, and 3-mercaptopyruvate sulfurtransferase revealed that supersulfides were still produced, suggesting the existence of compensatory or alternative synthetic pathways for supersulfide generation (24)
Conversely, a few studies reported high levels of vitamin B12 in the blood of patients with a worse COVID-19 outcome 48,49 potentially due to cytolysis leading to the release of intracellular B12 into the plasma and disrupted B12 clearance by the liver, which is often affected in these patients 50
Langerhans cells Vitamin D exerts multilayered immunomodulatory effects in the skin, particularly by regulating Langerhans cells (LCs), the principal antigen-presenting cell subset in the epidermis, thereby fine-tuning mucosal immune homeostasis
10.1016/j.cell.2012.03.042 23 DixonS
Kisspeptin is under study for ovulatory dysfunction specifically
