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GLP-1s may not be suitable for people who: Have a history of pancreatitis Have certain thyroid conditions (e.g., medullary thyroid cancer) Are pregnant or breastfeeding (depending on the specific medication) Have severe gastrointestinal conditions, like gastroparesis GLP-1 receptor agonists, including Tirzepatide, have been shown to lead to significant weight loss, with many people losing 10-15% of their body weight over time

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(2017) 312:E224E33

Prebreakfast self-monitoring plasma glucose (SMPG) results and individual patients glycemic target range should be used to titrate the dose [36]

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol

Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation