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doi:10.7860/JCDR/2016/18208.8127 If a good first response is seen, a second injection may be considered when the improvement from the first injection begins to taper off

Notably, mutations in TP53 not only change its conformation but also cause p53 aggregation, and p53 aggregation in cells is more consequential than conformational changes

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Metronomic Administration of Topotecan Alone and in combination with Docetaxel inhibits epithelial-mesenchymal transition in aggressive variant prostate cancers