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doi: 10.1053/j.gastro.2015.11.048

The study by Teichman et al

The Problem with NAC: Low Bioavailability One of NACs biggest limitations is its poor bioavailability

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Although our data align with the notion that inhibiting NMDA receptor signalling in the hypothalamus decreases food intake and body weight 8,40 , earlier studies have demonstrated that NMDA receptor antagonism in the brainstem attenuates vagus-mediated meal-related satiety 6,7,42