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MOTS-c has no relationship to this axis at all

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Estrogen deficiency and the decline of skin collagen were first observed in 1941 by Albright, who noticed that thin skin was more common in older women with osteoporotic fractures [21]

PLoS Pathog (2014) 10:e1004566.10.1371/journal.ppat.1004566 48 AmatoreDSgarbantiRAquilanoKBaldelliSLimongiDCivitelliLet alInfluenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS