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In parallel, dihydroorotate dehydrogenase (DHODH) and sulfide:quinone oxidoreductase (SQOR) were shown to generate ubiquinol (CoQ 10 H 2 , reduced) within mitochondria using dihydroorotate and selenide, respectively 23,24

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Baseline laboratory evaluation should include a complete blood count with differential, comprehensive metabolic panel, hepatic function tests, and tumor markers selected according to the patients demographics, family history, and clinical context