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4.1.2 Iron overload promotes joint ferroptosis by disrupting gut barrier Imbalanced host iron homeostasis remodels the structure of the gut microbiota, which can be manifested as changes in alpha-diversity, alterations in taxonomy composition and community dominance (Mao et al., 2024)

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Wet beriberi, which refers to infantile thiamine deficiency, is characterized by cardiomyopathy, heart failure, warm extremities, and pulmonary edema, with early symptoms including fatigue, nausea, and mental suppression ( Pan et al, in a in vivo study performed with transgenic mice, have shown that chronic treatment with benfotiamine, a thiamine derivate with better bioavailability, enhanced the spatial memory and reduced both amyloid plaque numbers and phosphorylated tau levels, suggesting that this thiamine derivative may be useful in clinical Alzheimers disease treatment, although others thiamine derivatives do not showed the same results ( Table 2 )