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Leptin the hormone that signals fullness and energy sufficiency may be resisted by the brain even when fat stores are adequate

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"It would be nice to optimize the brain's reward pathway to help our patients out though, and not have them suffer through the cravings." Anhedonia might be a dosing problem, not a drug problem Reports of anhedonia and emotional blunting on GLP-1 agonists have generated real concern

Treatment satisfaction and quality-of-life measures

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