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For example, CLIK-148 could be obtained with ~50% total isolated yield from the biocatalytic synthesis of (2 S ,3 S )- t -ES- Phe - b28 , followed by chemical condensation with 2-pyridylethylamine (Fig

Biochem Pharmacol 155:264274

N Engl J Med (2012) 366(24):224756

Minor side effects such as injection site pain, redness, or temporary headache are common and usually self-limiting