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Oral semaglutide 25mg achieved average weight loss of 16.6% at 64 weeks, while orforglipron 36mg achieved 12.4% at 72 weeks

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Market-Sizing and Forecasting: A hybrid top-down and bottom-up model was constructed, reconstructing demand from prescription volume data, patient population estimates, and treatment penetration rates across indications

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However, several clinical considerations may influence selection: Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use any GLP-1 receptor agonist