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[DOI] [PubMed] [Google Scholar] 94.Christensen, M., Knop, F

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In summary, CTGF causes synovial fibrosis by activating fibroblast and their transition into myofibroblast, stimulates the production of pro-inflammatory cytokines and thus promotes synovitis and catabolic, destructive processes in the articular cartilage of OA patients

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(Source 1) Vitamin C tends to be well-tolerated at recommended dosages, and some protocols may call for high doses of vitamin C