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The combination carries GI side effects from semaglutide (nausea, vomiting, diarrhea) plus potential naltrexone-related symptoms (dizziness, headache, insomnia) and requires liver monitoring because naltrexone can elevate enzymes

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At the highest dose (12 mg weekly), mean body weight reduction reached 24.2%, compared with a 2.1% reduction in the placebo arm

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Understanding whether you carry variants associated with GLP-1R sensitivity, GIPR signaling, or FTO-driven weight regulation may help provide context for your provider conversation about which GLP-1 option and dosing strategy align with your genetic profile