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All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

The STEP UP trial, published in The Lancet Diabetes & Endocrinology in September 2025, evaluated a higher investigational dose of semaglutide (7.2 mg, versus the currently approved 2.4 mg) in adults with obesity

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However, semaglutide users may experience mild fluid shifts or blood pressure changes

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