The MHRA advises patients on all GLP-1s to use contraception while taking GLP-1 medicines (including an additional barrier method for patients starting or increasing tirzepatide who are using oral contraception), as well as for a defined wash-out period afterwards before trying to get pregnant (see Figure 3)
Ozempic slows gastric emptying as part of its therapeutic action, which can lead to feelings of fullness, nausea, or indigestionparticularly when treatment is first initiated or the dose is increased
For the full background see our compounded vs FDA-approved breakdown
Conversely, when prednisone is tapered and discontinued, semaglutide's glucose-lowering effect may strengthen, potentially increasing hypoglycemia risk if doses remain unchanged
When to contact your GP : Discuss GLP-1 treatment if you have type 2 diabetes with suboptimal control despite lifestyle changes and other medications, or if you're struggling with obesity-related health complications despite sustained efforts at dietary modification and increased physical activity
People think they should be able to control this with willpower, he says
