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Sustained, uninterrupted stimulation causes homologous desensitization, meaning the receptor progressively loses its ability to respond

Nat Rev Mol Cell Biol (2021) 22(2):7595

If you go this route, attach a separate thin-gauge needle (27-31 gauge) for the actual injection to minimize discomfort

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Diagnosis First and foremost, they need to have a diagnosis of Type 2 diabetes mellitus

Nat Chem Biol 4(5):278286 [DOI] [PubMed] [Google Scholar] Wiseman EM, Bar-El Dadon S, Reifen R (2017) The vicious cycle of vitamin a deficiency: a review