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doi: 10.1056/NEJMra2202819 22 WilkinsonMSugumarKMilanSJHartACrockettACrossinghamI

Such concerns are driving dramatic increases in pediatric obesity treatment

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Individual experiences may, however, vary

Safety, Side Effects, and Medical Supervision Both sermorelin and tirzepatide are generally well-tolerated, though mild side effects such as nausea, injection site reactions, and fatigue may occur during dose escalation

At the most recent follow-up in October 2025, the patient weighed 78.18 kg (172 lb), representing a total weight reduction of 39.54 kg (87 lb), corresponding to a 33.6% decrease from baseline body weight