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Key Structural Differences# Head-to-Head: LEAD-6 Trial# The LEAD-6 trial (Buse et al., Lancet 2009) directly compared liraglutide 1.8 mg once daily with exenatide 10 mcg twice daily in 464 adults with type 2 diabetes inadequately controlled on metformin, sulfonylurea, or both over 26 weeks: Liraglutide was statistically superior for glycemic control and demonstrated better tolerability, with less persistent nausea and fewer hypoglycemia events

Metformin has a number of actions within the gut

What to watch for during reconstitution A properly reconstituting vial usually moves from dry cake to partially wetted material, then to a clear solution

Randomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome

Limiting alcohol consumption is also advisable, as alcohol provides empty calories and may interfere with weight loss efforts

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