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Metabolic measures 12 months after a randomised controlled trial of treatment of clozapine associated obesity and diabetes with exenatide (CODEX)

Noteworthily, we observed that long-acting GLP-1 RAs offer more pronounced benefits, potentially due to their sustained pharmacological action, suggesting a dependency on pharmacokinetic profiles for maximal therapeutic impact

"I do think we're all going to have to be a little bit patient, because there is probably going to be a bit of a strain on clinics and pharmacies for the next couple of months as people very excitedly start these medications," Francavilla said

Prioritizing protein intake at 0.7 to 1.0 grams per pound of body weight, staying well hydrated, exercising consistently with an emphasis on resistance training, sleeping seven to nine hours nightly, and managing stress all meaningfully accelerate results

Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations