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48 A recent phase III RCT of cenicriviroc in NASH patients (AURORA) was terminated early, due to a lack of benefit based on the part 1 results

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The compound remains available through research chemical websites but is not approved for human use in any jurisdiction

In a transgenic model of AD, SAMe administration reversed DNA hypomethylation, including at the BACE1 promoter (51), leading to decreased A accumulation and cognitive improvements

Nayak, T.K., Garmestani, K., Baidoo, K.E., Milenic, D.E

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