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If you're on a 1ml weekly protocol and seeing no measurable change after six weeks, the problem is almost never 'too low a dose.' It's either formulation quality (underdosed methionine or choline), dietary interference (you're in maintenance calories, not deficit), or liver saturation (you're already consuming high dietary methionine and adding more doesn't shift the pathway further)

Stefanello, F

Very low or high blood levels of homocysteine can indicate a B12, folate, and/or B6 deficiency (21)

Safety issues of tirzepatide (pancreatitis and gallbladder or biliary disease) in type 2 diabetes and obesity: a systematic review and meta-analysis

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