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IGF-1 LR3: IGFBP-Resistant IGF-1R Agonist Pharmacology IGF-1 LR3 (Long R3 IGF-1, [Arg3]IGF-1 extended with a 13-amino-acid N-terminal extension, 83 total amino acids) is a synthetic analogue of human IGF-1 engineered for two properties: (1) substitution of glutamic acid at position 3 with arginine disrupts the binding site for IGF Binding Proteins (IGFBPs 16), reducing IGFBP affinity approximately 1000-fold compared to native IGF-1

Corilagin reduces acetaminophen-induced hepatotoxicity through MAPK and NF-B signaling pathway in a mouse model

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27. Nonaka D, Chiriboga L & Rubin BP

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10.1016/j.envres.2023.115912 320 TalemyF