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When these autonomic fibers are damaged in Long COVID or ME/CFS, the entire autonomic nervous system becomes destabilized, leading to a condition known as dysautonomia

however, there is not much scientific research to support this

You may notice a modest reduction in peak performance during high-intensity efforts as phosphocreatine stores return to baseline, but effects are typically subtle and temporary

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Heat above 86F (30C) causes the active proteins to break down, reducing effectiveness